This study was designed to investigate anabolic effects of parentral administration of parathyroid hormone (Forteo) in wistar rats. Twelve female wistar rats of 8 weeks old were randomly divided in two groups (Group I and Group II); six female rats in each group. Animals of Group I served as vehicle control or placebo treated group and Group II as Parathyroid hormone (PTH) treated group at dose rate of 400 µg/kg body weight on every alternate day for 42 consecutive days. Parathyroid hormone was administered in the treatment group by subcutaneous route. Animals of control group were treated with normal saline and handled in similar manner as treatment group. Animal were observed for clinical biochemistry investigations and histomorphological evaluation of femur bone. Significant increase in bone alkaline phosphatase, serum calcium and phosphorus were observed in PTH treated group of animals compared to concurrent control animals. Histomorphological evaluation of femur bone in PTH treated rats revealed excessive calcification and reduction in bone marrow space due to excessive osteoblastic activity of bony tissue. Mid shaft of femur bone in PTH treated rats also revealed excessive condensation of osteoid tissue due to anabolic effects of Parathyroid hormone.
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